Fig. 7 | Oncogene

Fig. 7

From: Therapeutic targeting of the PI4K2A/PKR lysosome network is critical for misfolded protein clearance and survival in cancer cells

Fig. 7

Prognostic significance of PKR and PI4K2A expression in cancer patients. a, b PKR and PI4K2A are encoded by the EIF2AK2 and PI4K2A genes, respectively. In the TCGA data analysis, high levels of EIF2AK2 (a) and PI4K2A (b) gene expression were associated with low overall survival rates in breast cancer patients. c Our proposed mechanism of action of PI4K2A network in normal cells. ER, endoplasmic reticulum. d Our proposed mechanism of action of Pac 1 in cancer cells

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