Fig. 7 | Oncogene

Fig. 7

From: A drug library screen identifies Carbenoxolone as novel FOXO inhibitor that overcomes FOXO3-mediated chemoprotection in high-stage neuroblastoma

Fig. 7

Proposed mechanism how silencing of the FOXO3-transcriptional activity by CBX affects cell death in NB cells. In low-stage “FOXO3-sensitive” NB cells FOXO3 inhibition prevents BIM induction and thus FOXO3-dependent cell death. On the other hand, in the “FOXO3-resistant” high-stage derived NB cells, FOXO3-mediated death protection by SESN3 expression is abrogated by CBX treatment. Consequently FOXO3 inhibition by CBX sensitizes the resistant NB cells to chemotherapy

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