Fig. 1

RNA signature of connexins (Cxs) in leukemic niche partners shows a specific expression profile in leukemic BM-MSCs. The expression of 23 Cxs was quantified by RT-qPCR (Supplementary Table 1). a The expression profile of detectable Cxs in 39 primary AML cells, six AML cell lines, and eight normal BM-CD34⁺ cells (pooled samples). Data were normalized to housekeeping genes and presented as ΔCt. b The expression profile of detectable Cxs in 19 primary AML BM-MSCs compared with 30 normal BM-MSCs. Data were normalized to reference genes and are presented as ΔCt. Heatmap colors reflect expression levels as ΔCt mean values (red: high expression, green: low expression). Comparative expression in BM-MSCs (leukemic BM-MSCs vs. normal BM-MSCs): *P < 0.05; **P < 0.01; ***P < 0.001