Fig. 8 | Oncogene

Fig. 8

From: Disruption of gap junctions attenuates acute myeloid leukemia chemoresistance induced by bone marrow mesenchymal stromal cells

Fig. 8

Schematic model of the antileukemic effect of CBX, a disruptor of gap junctions, in the context of the leukemic niche. CBX decreases the proliferation of leukemic cells by promoting apoptosis via global extinction of energy metabolism (oxidative phosphorylation and glycolysis). The most important antileukemic effect is observed at the level of the leukemic niche, since CBX reduces the chemoresistance to Ara-C triggered by BM-MSCs

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