Fig. 1: Depletion of PIERCE1 inhibits lung cancer cell growth. | Oncogene

Fig. 1: Depletion of PIERCE1 inhibits lung cancer cell growth.

From: Impaired AKT signaling and lung tumorigenesis by PIERCE1 ablation in KRAS-mutant non-small cell lung cancer

Fig. 1

a Kaplan–Meier plotter analyses of overall survival (OS) in 1926 lung cancer patients with respect to PIERCE1 expression low (black) and high (red) groups. Auto select best cutoff was chosen for the analyses. The hazard ratio (HR) and P values were indicated. b Monitoring of growth of lung cancer cell lines by crystal violet staining 72 hours after siRNA transfection against control (siCTL) and PIERCE1 (siP#1 and siP#3). Quantitated relative intensities of crystal violet staining of PIERCE1 knockdown (KD) cells to the controls were indicated in the bottom middle of each well. The growth rates of A549 (c) and H460 (d) cell lines that have stable PIERCE1 KD with shRNA were compared with those of the control on the indicated days. e Growth rates of parental (black) and Doxy-inducible PIERCE1 overexpressing A549 cell lines with or without doxycycline treatment (red and blue, respectively) at the indicated days. Error bars are ±SD *P < 0.05.

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