Fig. 7: Targeting the FGFR2–c-Jun–YAP1 axis by small molecules. | Oncogene

Fig. 7: Targeting the FGFR2–c-Jun–YAP1 axis by small molecules.

From: FGF18–FGFR2 signaling triggers the activation of c-Jun–YAP1 axis to promote carcinogenesis in a subgroup of gastric cancer patients and indicates translational potential

Fig. 7

a Colony formation assays of MGC-803 administrated with FGFR2 inhibitor AZD4547 (5 µM) or YAP1 inhibitor verteporfin (VP, 2 µM) alone, or in combination (*p < 0.05; **p < 0.001). b Co-administration of VP and AZD4547 synergistically inhibited MGC-803-derived tumor growth compared with the effects of single AZD4547 or VP treatment (*p < 0.05). The xenograft sizes of each group were measured every 4 days. 0.1% DMSO in PBS as the vehicle control. c Representative IHC images of FGFR2, YAP1, Ki-67 in different MGC-803 xenograft sections (scale bar, 100 μm). d Expression levels of the indicated biomarkers were quantified by ImageJ (n = 3 areas; *p < 0.05).

Back to article page