Fig. 8: The FGF18–FGFR2 signaling activates YAP1 expression through MAPK–c-Jun cascade. | Oncogene

Fig. 8: The FGF18–FGFR2 signaling activates YAP1 expression through MAPK–c-Jun cascade.

From: FGF18–FGFR2 signaling triggers the activation of c-Jun–YAP1 axis to promote carcinogenesis in a subgroup of gastric cancer patients and indicates translational potential

Fig. 8

FGF18–FGFR2 regulate the cytoskeleton and YAP1 activation, while Hippo signaling pathway is independent. As a transcription co-activator, YAP1 binds with TEADs to regulate the oncogenic downstream expression. Co-targeting FGFR2 and YAP1 might serves as a promising therapeutic strategy for the FGFR2–c-Jun–YAP1 co-activation GC cases.

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