Fig. 1: RNA-seq analysis of glioma and characterization of BCYRN1. | Oncogene

Fig. 1: RNA-seq analysis of glioma and characterization of BCYRN1.

From: LncRNA BCYRN1 inhibits glioma tumorigenesis by competitively binding with miR-619-5p to regulate CUEDC2 expression and the PTEN/AKT/p21 pathway

Fig. 1

a Heatmap of correlation for all transcripts between each sample. N normal tissue, G glioma tissue. b Circos plots of lncRNAs in the human genome (hg19). The outer tracks represent the cytoband ideogram of chromosome. For the two tracks, the outer one (blue) represents the levels of lncRNAs in normal tissues and the inner one (red) represents the levels in glioma tissues. c Volcano plots performed the expressed lncRNAs. Blue and red dots represent downregulated and upregulated lncRNAs respectively in glioma tissues compared with normal tissues. Black dots indicate the lncRNAs with no significant differences. d Expression level of BCYRN1 was identified in 22 normal tissues and 46 low grade glioma tissues and 65 high grade glioma tissues by RT-qPCR. e Kaplan–Meier plots of overall survivals in glioma patients with high (n = 338) and low (n = 338) levels of BCYRN1. f Levels of BCYRN1 in the nuclear and cytoplasmic fractions of T98G and U251 cells. g RT-qPCR analysis of the relative expression of BCYRN1 in five glioma cell lines. Data were from three independent experiments. In (d), error bars, S.E.M. ****p < 0.0001 by two-tailed Student’s t test. In (e), error bars, S.E.M. P value was calculated by Mantel–Cox log rank test.

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