Fig. 6: BCYRN1 inhibits glioma progression through CUEDC2/PTEN/Akt/P21 signaling pathway. | Oncogene

Fig. 6: BCYRN1 inhibits glioma progression through CUEDC2/PTEN/Akt/P21 signaling pathway.

From: LncRNA BCYRN1 inhibits glioma tumorigenesis by competitively binding with miR-619-5p to regulate CUEDC2 expression and the PTEN/AKT/p21 pathway

Fig. 6

a GO analysis and annotation of 44 targeted mRNAs in biological processes. b The protein expression levels of PI3K/Akt signaling related proteins in T98G cells treated with BCYRN1 siRNAs. c The protein expression levels of PI3K/Akt signaling related proteins in T98G cells treated with miR-619-5p mimic. d The protein expression levels of PI3K/Akt signaling related proteins in T98G cells treated with CUEDC2 siRNAs. e The protein expression level of PI3K/Akt signaling related proteins in T98G cells treated with miR-619-5p inhibitor alone or co-transfection with BCYRN1 siRNAs. f Hypothesis diagram illustrates function and mechanism of BCYRN1 in glioma. Error bars, S.E.M. from three independent experiments. ****p < 0.0001 by two-tailed Student’s t test. #P was used to show the significance between NC and Si-BCYRN1-2 or NC and Si-CUEDC2-2.

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