Fig. 2: Restoring SUV39H1 expression suppressed leukemic progression of MLL-AF9-induced murine AML.
From: SUV39H1 regulates the progression of MLL-AF9-induced acute myeloid leukemia
a Experimental scheme of establishing Suv39h1 overexpressing (SUV-OE) and control murine AML models. b Immunoblot analysis of Suv39h1 and H3K9me3 levels in whole BM cells from control or SUV-OE tertiary recipients. Densitometry was determined by ImageJ, n = 2. c, d Kaplan–Meier survival curve of secondary recipients (transplanted with P0 cells, 1 × 103 cells per group for (c) and 1 × 104 cells per group for (d). n = 10, **P < 0.01, ***P < 0.001, Mantel–Cox test. e, f Kaplan–Meier survival curve of tertiary recipients (transplanted with P1 cells, 1 × 103 cells per group for (e) and 5 × 103 cells per group for (f). n = 10, ***P < 0.001, Mantel–Cox test.
