Fig. 6: Synergistic inhibitory effect of DIMATE and CDDP in NSCLC cells. | Oncogene

Fig. 6: Synergistic inhibitory effect of DIMATE and CDDP in NSCLC cells.

From: Dual disruption of aldehyde dehydrogenases 1 and 3 promotes functional changes in the glutathione redox system and enhances chemosensitivity in nonsmall cell lung cancer

Fig. 6

a CI curve analysis (Chou–Talalay plot) for DIMATE plus CDDP in HCC827, H460, Hop62, and H2122 cells, indicating synergy at medium and high doses. CI values less than, equal to, or greater than 1 indicate synergy, additivity, or antagonism, respectively. The effect level (Fa) indicates the fractional inhibition for each CI. b Representative micro-CT images showing the lung anatomy of mice with orthotopic HCC827 xenografts treated with either DIMATE, CDDP or DIMATE plus CDDP. Macroscopic tumor lesions in the lungs are indicated with arrows. The lower graph shows the tumor volumes calculated from CT scans at the indicated time points. c Representative images of pulmonary tumors at necropsy stained with H&E (20X magnification). d Quantification of tumor necrosis within tumor sections by densitometry.

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