Fig. 6: Proposed model illustrating mPTP opening in wt and Cdk5−/− MEFs.
From: mPTP opening caused by Cdk5 loss is due to increased mitochondrial Ca2+ uptake
Loss of Cdk5 that localizes in MAM causes reduced distance between ER and mitochondria, and increased number and length of ER-mitochondria contact sites, causing increased Ca2+ transfer from the ER to the mitochondria, which leads to increased [Ca2+]mt and subsequently, mPTP opening.
