Fig. 6: The function of the EGFR-ZNF263 signaling axis glioblastoma cells.
From: The EGFR-ZNF263 signaling axis silences SIX3 in glioblastoma epigenetically
a Immunoblotting showing that overexpression of EGFR-vIII increases ZNF263 expression, while decreasing SIX3 expression. Knockdown of ZNF263 or treatment with Trametinib restores SIX3 expression after overexpression of EGFR-vIII in human astrocytoma cells. b Transwell and (c) soft-agar colony formation assay showing that knockdown of ZNF263, overexpression of SIX3 or treatment with Trametinib decreases invasion and anchorage-independent growth of astrocytoma cells with EGFR-vIII overexpression. *p < 0.05; **p < 0.01; ***p < 0.001.
