Fig. 3: EBV life cycle in stomach epithelial cells and the oncogenic properties in gastric carcinoma. | Oncogene

Fig. 3: EBV life cycle in stomach epithelial cells and the oncogenic properties in gastric carcinoma.

From: Gastric cancer: genome damaged by bugs

Fig. 3

① Dissociative EBV from saliva or B cell enters stomach epithelial cells with the help of host receptor such as integrins, ephrin receptor A2, and NMHCIIA. Interaction of B cell and epithelial cell also facilitates the entry of EBV. ② Naked EBV-DNA is transported to nucleus, and then goes through ③ circulation, ④ chromatination, and CpG methylation. The latent infection is established followed by viral genome ⑤ transcription and ⑥ translation. The transcription products include ⑦ EBERs and ⑧ BART-miRNAs. The translational products are ⑨ LMP2A and ⑩ EBNA1. The oncogenic factors corporately promote gastric tumorigenesis. EBV can also induce ⑪ globally genomic methylation of the host cells.

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