Table 3 Distribution of recurrent somatic substitutions in prostate tumors in Caucasian men (n = 33).

From: Somatic mutations in the DNA repairome in prostate cancers in African Americans and Caucasians

Variant

DNA Repair Pathways

Incidence

Frequency (%)

POLB

BER

  

 p.E216K

–

8

24

EXO1

MMR

  

 p.H354R

–

3

1

 p.E670G

–

6

24

ERCC6

NER

  

 p.M1097V

–

3

1

RFC1

NER

  

 p.P847P

–

3

1

BRCA2

FA

  

 p.N372H

–

4

1.2

AR

   

 p.E213*

 

2

6

  1. Missense substitutions are indicated by the normal amino acid and the codon number followed by the mutant amino acid, in one letter code, and for protein p, frequencies are approximate.
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