Fig. 4: LXRα protein expression is correlated with Pgp expression and is a molecular marker of poor prognosis in ER-negative breast cancer patients. | Oncogene

Fig. 4: LXRα protein expression is correlated with Pgp expression and is a molecular marker of poor prognosis in ER-negative breast cancer patients.

From: Liver x receptor alpha drives chemoresistance in response to side-chain hydroxycholesterols in triple negative breast cancer

Fig. 4

A Correlation analysis between LXR protein expression and matched mRNA of Pgp in 47 ER-negative breast tumors (relative to HPRT). Line indicates linear regression, correlations calculated using Pearson correlation. Kaplan–Meier survival plots following stratification of the cohort into high and low LXRα (B) and Pgp (C) expression. Log-rank tests used to calculate significance. D Tissue microarray of 148 TNBC tumors stained for indicated proteins determined by immunohistochemistry and correlated with Pgp protein (left) and disease-free survival (right). E scOHC concentrations determined by LC-MS/MS and correlated with Pgp protein (left) and disease-free survival (right). Correlations calculated with Pearson’s test and survival differences with log-rank test and Kaplan–Meier curves.

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