Fig. 3: PSMD1 and PSMD3 are upregulated during CML disease progression. | Oncogene

Fig. 3: PSMD1 and PSMD3 are upregulated during CML disease progression.

From: Proteasome 26S subunit, non-ATPases 1 (PSMD1) and 3 (PSMD3), play an oncogenic role in chronic myeloid leukemia by stabilizing nuclear factor-kappa B

Fig. 3

RNA-seq data demonstrated increased PSMD1 (A) and PSMD3 (B) mRNA levels in mononuclear cells from BP-CML (n = 10) compared to CP-CML (n = 13) and AP-CML (n = 8) patients demonstrating BCR-ABL1-independent TKI resistance. C Immunoblot shows PSMD1 and PSMD3 protein levels in CD34+ cells from cord blood (lanes 1–2) versus a CP-CML patient (lane 3). β-actin was assessed as a loading control.

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