Fig. 1: Expression of ErbB2 sialylated glycoforms in intestinal-type gastric carcinoma. | Oncogene

Fig. 1: Expression of ErbB2 sialylated glycoforms in intestinal-type gastric carcinoma.

From: ST6Gal1 targets the ectodomain of ErbB2 in a site-specific manner and regulates gastric cancer cell sensitivity to trastuzumab

Fig. 1

Representative individual (immuno)histochemical detection of: ErbB2 (A–F), sialyl Lewis a (SLea) (G–I), and Sambucus nigra agglutinin (SNA) (α2,6-linked sialic acid (α2,6NeuAc)) (J–L) in gastric carcinoma tissue sections; Parallel in situ brightfield Proximity Ligation Assay (PLA) analysis of ErbB2-SLea (M–O) and ErbB2-SNA (P–R) molecular proximity; representative individual immunohistochemical detection of ST6Gal1 (S–U) in gastric carcinoma tissue sections; images were acquired under ×200 and ×630 (inserts) magnifications.

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