Fig. 2: Tumors that harbor a mut-p53 allele often retain wild-type TP53.
From: Mutant p53 elicits context-dependent pro-tumorigenic phenotypes
A The allele frequencies of R273C-TP53, R273H-TP53, and R273L-TP53 in all cancers (left; MSK-IMPACT) and prostate cancer (right; studies with available allele frequency data—see “Materials and methods”). B The copy number changes for TP53-R273 mutations are observed as both diploid (retaining a wt-p53 allele; heterozygous) or shallow deletion (loss of heterozygosity) using the TCGA Pan Cancer Cohort (left; analyzed January 2020) or all available non-redundant prostate cancer studies—right (see “Materials and methods” for studies used).
