Fig. 6: Administration of Pol I inhibitor CX-5461 efficiently suppressed tumor growth in Znf545Δ/ΔApcMin/+ mice. | Oncogene

Fig. 6: Administration of Pol I inhibitor CX-5461 efficiently suppressed tumor growth in Znf545Δ/ΔApcMin/+ mice.

From: ZNF545 loss promotes ribosome biogenesis and protein translation to initiate colorectal tumorigenesis in mice

Fig. 6

a Drug sensitivity to CX-5461. Cells were treated with CX-5461 for 72 h (0, 10 nM, 100 nM, 500 nM, 1 µM, 10 µM, 50 µM, 100 µM; each concentration: n = 5). b Scheme for the experimental design of CX-5461 treatment in vivo. Representative photographs (c) and hematoxylin and eosin (H&E) staining (d) of the intestines from control and CX-5461-treated Znf545Δ/ΔApcMin/+ mice at 3 months of age. e The body weight, colon tumor number, colon tumor burden of control and CX-5461-treated Znf545Δ/ΔApcMin/+ mice at 3 months of age (each group: n = 8). All data represent mean ± SD (two-sided Student’s t test). ns, not significant; *P < 0.05. f Scheme of the proposed mechanism of malignant transformation by ZNF545 loss.

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