Fig. 6: Immunohistochemical staining of C-MYC, STAT3, and p-STAT3 in ovarian cancer. | Oncogene

Fig. 6: Immunohistochemical staining of C-MYC, STAT3, and p-STAT3 in ovarian cancer.

From: FBP1 regulates proliferation, metastasis, and chemoresistance by participating in C-MYC/STAT3 signaling axis in ovarian cancer

Fig. 6

A Representative images of biopsies containing negative, weak, moderate, and strong expression of C-MYC, STAT3, and p-STAT3 (all 400×). B Survival analysis of patients by Kaplan–Meier plots and log-rank tests. Patients were categorized as having high or low expression of C-MYC, STAT3, and p-STAT3 on the basis of IHC staining scores. H high; L low. Only IHC scores ≥3 were considered high. C Correlation of IHC scores between FBP1 and C-MYC, STAT3, and p-STAT3. D Schematic model showing the role of C-MYC-FBP1-STAT3 signaling axis in the regulation of cell proliferation, metastasis, and chemosensitivity.

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