Table 1 IC50 (μM concentrations) of MK-8776 (MK) and MK-8776+olaparib (MK + Ola) in NB cell lines.
From: A combination of PARP and CHK1 inhibitors efficiently antagonizes MYCN-driven tumors
Cell line | MYCN status | MK | MK + Ola |
|---|---|---|---|
LAN-1 | Amp. | 3.01 | 0.80 |
IMR-32 | Amp. | 3.58 | 0.005 |
LAN-5 | Amp. | 0.11 | 0.01 |
KELLY | Amp. | 0.42 | 0.04 |
HTLA-230 | Amp. | 0.31 | 0.06 |
SK-N-AS | Non amp. | 118.9 | 10.9 |
SK-N-SH | Non amp. | 85.0 | 22.2 |
GI-ME-N | Non amp. | 80.8 | 25.4 |
