Fig. 1: Intron-retention (IR) events in plasma cells from multiple myeloma (MM) patients are associated with altered RNA splicing.
From: Intron retention-induced neoantigen load correlates with unfavorable prognosis in multiple myeloma
A Spliceosome is among the top significant pathways involving upregulated genes in newly diagnosed MM compared with healthy controls from GSE110486. B Gene enrichment plot for spliceosome pathway genes in MM samples compared with healthy controls from GSE110486. NES, normalized enrichment score. C Serine and arginine-rich splicing factor (SRSF) gene expression was associated with shorter overall survival time in MM; results were obtained from 767 newly diagnosed multiple myeloma (NDMM) patients in the MMRF cohort. D Comparison of the number of IR events in primary MM samples from MMRF (n = 767) compared with normal plasma cell samples from GEO (n = 13). Violin plots show the median and 25th and 75th percentiles (box) and the 95% confidence interval (whiskers). P value was determined using the Mann-Whitney test.
