Fig. 2: ULBR inactivation affects Src oncogenic activity.
From: Regulation of Src tumor activity by its N-terminal intrinsically disordered region
a Strategy of ULBR inactivation. Molecular properties of Src-ULBR including amino acids involved in this process are highlighted. b the level of Src expression in NIH3T3 cells transduced with indicated Src constructs. Anchorage-independent cell growth (c) and invasion (d) of indicated Src-transformed NIH3T3 cells. e The level of Src expression and activity in SW620 colon cancer cells transduced with indicated Src constructs. Anchorage-independent growth (f) and invasion (g) of SW620 cancer cells expressing indicated Src constructs. The histograms show the percentage of colonies in soft agar normalized to the maximal condition set a 100% (colonies) and the percentage of migrating cells in the matrigel matrix normalized to control condition set at 100% (cell invasion). Is shown the mean ± SD; n = 3; ns: p > 0.05; *p < 0.05; **p < 0.01; ***p < 0.001; Student’s t test.
