Fig. 3: ULBR inactive mutations affects Src tumor activity in nude mice.
From: Regulation of Src tumor activity by its N-terminal intrinsically disordered region
a, b Time-course of tumor development in nude mice subcutaneously inoculated with SW620 tumor cells that were transduced with control (mock) or indicated Src construct. Analysis of tumor cell proliferation (c), apoptosis (d) and angiogenesis (e) from indicated tumor sections. Representative sections and quantification of immunohistochemical analysis showing tumor cell proliferation (anti-ki67), apoptosis (anti-cleaved Caspase 3) and angiogenesis (anti-CD31; length of blood vessels) in xenograft tumors derived from SW620 cells transduced with indicated Src construct. Is shown the mean ± SEM (a) and the mean ± SD (b–e); n > 8 mice per cohort; ns: p > 0.05; *p < 0.05; **p < 0.01; ***p < 0.001; Student’s t test.
