Fig. 1: Elevated TIMP1 levels in tumour stroma of CRC liver MET. | Oncogene

Fig. 1: Elevated TIMP1 levels in tumour stroma of CRC liver MET.

From: Extravesicular TIMP-1 is a non-invasive independent prognostic marker and potential therapeutic target in colorectal liver metastases

Fig. 1

A, B Representative immunohistochemial (IHC) images showing localisation patterns of TIMP1 in CRC (n = 81) and CRC liver MET (n = 80). C Quantification of TIMP1 expression in the tumour core (TC) and invasive margin (IM) of the tumour as identified by IHC in CRC and CRC liver MET. D Quantification of TIMP1 expression in the stroma (TC and IM) as identified by IHC in CRC and CRC liver MET. E Percentage of tissues with TIMP1high (score 3) and TIMP1low (score 0–2) stroma in the IM and TC of CRC and CRC liver MET. F Kaplan-Meier curve depicting progression-free survival for CRC liver MET patients with TIMP1high (n = 16) compared to TIMP1low (n = 30) stroma in IM. Scale bars: 300 µm. P values were calculated by unpaired t-test or Log-rank (Mantel-Cox) test (F). *p < 0.05, **p < 0.01, ****p < 0.0001, ns not significant.

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