Table 1 Multivariable Cox Proportional Hazards Regression for CRC liver MET patients in the analysed cohorts.

From: Extravesicular TIMP-1 is a non-invasive independent prognostic marker and potential therapeutic target in colorectal liver metastases

Factor

Discovery Cohort

Validation Cohort I

Validation Cohort II (external)

 

95% C.I for Exp(B)

  

95% C.I for Exp(B)

  

95% C.I for Exp(B)

 

Exp(B)

Lower

Upper

p value

Exp(B)

Lower

Upper

p value

Exp(B)

Lower

Upper

p value

Age

1.015

0.991

1.039

0.220

1.010

0.968

1.055

0.635

0.988

0.945

1.034

0.612

Sex

1.108

0.687

1.787

0.673

1.361

0.498

3.722

0.548

1.046

0.369

2.963

0.933

UICC

0.993

0.979

1.008

0.362

1.076

0.653

1.773

0.774

100458.851

0.000

N/A

0.990

KRAS

1.001

0.995

1.006

0.774

2.906

0.625

13.503

0.174

N/A

N/A

N/A

N/A

Pre-operative Theraphy

1.515

0.908

2.529

0.112

0.995

0.985

1.006

0.372

N/A

N/A

N/A

N/A

Median TIMP1

1.902

1.218

2.968

0.005

5.694

1.952

16.613

0.001

18.250

5.588

59.606

0.000

  1. EXP(B): Odds ratio; CI Confidence interval.
  2. P values indicated in bold denote statistical significance.
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