Fig. 2: Tumor evolution of endometrial carcinomas.
From: Intratumor genetic heterogeneity and clonal evolution to decode endometrial cancer progression
Venn diagrams representing the somatic mutations shared by the primary tumor sections and metastases analyzed by WES. The numbers of the genetic variants are shown, and the percentages are in brackets. Phylogenetic trees based on somatic mutations depicting the evolution of two primary tumor areas and a metastasis. The length of the branches is proportional to the number of shared or private somatic mutations. The pie charts represent the mutational signatures previously described [29] for the shared or private somatic mutations: A EEC3, B EEC4, C EEC5, D EEC6, E EEC7. WES whole-exome sequencing, EEC endometrioid endometrial carcinoma.
