Fig. 3: Targeted sequencing validation for MSI endometrial carcinomas.
From: Intratumor genetic heterogeneity and clonal evolution to decode endometrial cancer progression
Validation of the pathogenic somatic mutations identified by targeted sequencing in primary tumor regions (T) and metastatic regions (M) of A EEC5, B EEC7 and C EEC6. The mutation subtypes are colored according to the legend and the origin of the tumor sections is indicated in the graphical representation: green line represents the peritoneum and orange line the diaphragm. Below each case the phylogenetic trees generated according to the presence or absence of the somatic mutations detected in the validation analysis are shown. MSI microsatellite instability, EEC endometrioid endometrial carcinoma.
