Fig. 6: TYMP is a potential antiangiogenic target for HCC.
From: The proteomic characterization of the peritumor microenvironment in human hepatocellular carcinoma
A–C Action of TPI (100 mg/kg) and Kin59 (30 mg/kg) in a liver orthotopic transplantation tumor model with H22 cell lines in BALB/c mice. Body weight (D) and Tumor weight (E) of BALB/c mice in different group. Data are presented as the mean ± SD. ***P < 0.001 compared with normal; #P < 0.05 compared with bevacizumab group. F Representative immunostaining images of PECAM1 (CD31), marker of microvascular density in tumor tissues for each group (Scale bar: 50 μm). G microvascular density analysis of PECAM1 (CD31) immunostaining, data are presented as the mean ± SD. H Effect of TPI on proliferation of H22 mouse liver cancer cells after treatment for 24 h and 48 h. I Expression of mRNA of TYMP related proteins in different groups, data are presented as the mean ± SD. *P < 0.05, **P < 0.01, ***P < 0.001 compared with model; #P < 0.05, ##P < 0.01, ###P < 0.001 compared with normal. J Schematic of the mechanism underlying the upregulation of TYMP expression in angiogenesis.
