Fig. 4: BIX10294 treatment inhibited capacity for vasculogenic mimicry in EWS cell lines. | Oncogene

Fig. 4: BIX10294 treatment inhibited capacity for vasculogenic mimicry in EWS cell lines.

From: Selective histone methyltransferase G9a inhibition reduces metastatic development of Ewing sarcoma through the epigenetic regulation of NEU1

Fig. 4

A BIX10294 impaired the capacity for vasculogenic mimicry (VM) in pre-treated HUVEC and MUM 2B cell lines. B The expression levels of VM biomarker genes were inhibited by BIX10294 in pre-treated HUVEC and MUM 2B cell lines. C Pharmacological inhibition of G9a impaired the ability of VM in pretreated CADO-ES and RM82 cell lines. D The levels of expression of VM biomarker genes were partially inhibited by BIX10294 in pre-treated EWS cell lines. The number of tubes formed during VM progress was reduced in (E) pre-treated HUVEC and MUM 2B cell lines, and in (F) pre-treated CADO-ES and RM82 cell lines. *p < 0.05; **p < 0.01; ***p < 0.001.

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