Fig. 4: Gene silencing of PDGF-Rα/β with siRNA induces neurite-like process outgrowth in U87 GBM cells and G179 GSCs. | Oncogene

Fig. 4: Gene silencing of PDGF-Rα/β with siRNA induces neurite-like process outgrowth in U87 GBM cells and G179 GSCs.

From: PDGF-R inhibition induces glioblastoma cell differentiation via DUSP1/p38MAPK signalling

Fig. 4

A, B Average length of neurite-like process was determined in U87 GBM cells (A) and G179 GSCs (B) treated for 48 h with 50 nM and 100 nM siRNA CTRL, PDGF-Rα, PDGF-Rβ and PDGF-Rα and β. Representative images are shown with neurite-like processes indicated with red arrows. The mean ± SD of minimum n = 3 independent experiments is displayed, representative images shown *p ≤ 0.05 **p ≤ 0.01 ***p ≤ 0.001 (two-tailed t-test).

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