Fig. 5: p38 inhibition sensitizes tumor cells to standard chemotherapy.
From: Role of p38 MAP kinase in cancer stem cells and metastasis
Schematic of the effects of A chemotherapy alone, B pre-treatment with the p38 inhibitor SB203580 followed by chemotherapy, and C co-treatment with the p38 inhibitor SB203580 and chemotherapy. The combination treatments overcome the chemoresistance of tumor cells by inhibiting the formation of CSCs and decreasing cell viability and tumorigenicity. This can lead to lower rates of cancer recurrence and higher survival rates.
