Fig. 2: Potential oncogenic ncRNA actions through IGFBP-2.
From: Noncoding RNA actions through IGFs and IGF binding proteins in cancer
MiR-1184 [45] and miR126 [40] can bind to 3'-UTR sites of IGFBP-2 mRNA to repress its translation. CircVANGL1, which sponges miR-1184, increases IGFBP-2 expression [45]. HOTAIR also increases IGFBP-2, possibly mediated by sponging miR-34a [48, 49]. MiR-34a suppression promotes IGFBP-2 secretion by RAB6A+ vesicles [50]. IGFBP-2 stimulates oncogenic signaling through IGF1R [40], but whether this involves IGF binding by IGFBP-2 is unclear. A potential mechanism involves interaction with integrin-β1, which forms a signaling complex with IGF1R including the scaffold protein RACK1, leading to proliferative ERK activation and other oncogenic signaling [47].
