Fig. 1: Images from cancer-focused Molecule of the Month articles.
From: Molecular explorations of cancer biology and therapeutics at PDB-101
(left) Artistic conception of VegF signaling. VegF (magenta, top left) arrives at the potential site of a new blood vessel by traveling through the blood plasma (tan). VegF brings together two copies of VegFR (top center, lavender/yellow) to form an active dimer. Active VegFR then initiates a signal cascade that leads to intracellular phosphorylation of many proteins, including cadherin (green). The phosphorylated cadherins separate, making room for new blood vessels. Full image available at PDB-101 and in the article on Vascular Endothelial Growth Factor (VegF) and Angiogenesis [14]. (right) Trastuzumab (red/pink) antibody bound to HER2 (blue). The cell membrane is shown schematically in gray. The illustration is built from three PDB structures: the extracellular domain with the antigen-binding fragment (Fab) of trastuzumab (1n8z [15]), the kinase domain inside the cell (3pp0 [16]), and the transmembrane domain (2ks1 [17]). Image available from the article on HER2/neu and Trastuzumab [9].
