Fig. 2: SMARCE1 affects the proliferation and tumorigenicity of neuroblastoma cells. | Oncogene

Fig. 2: SMARCE1 affects the proliferation and tumorigenicity of neuroblastoma cells.

From: SMARCE1 promotes neuroblastoma tumorigenesis through assisting MYCN-mediated transcriptional activation

Fig. 2

A Real-time qPCR and immunoblot analyses of SMARCE1 in SK-N-BE(2)C and IMR32 cells with SMARCE1 shRNA knockdown. B Cell viability of SMARCE1 shRNA and the GFP control in SK-N-BE(2)C and IMR32 cells were assessed. C, D Xenograft assay of BE(2)-C and IMR32 cells with inducible expression of shGFP or shSMARCE1. Tumor weight was analyzed by scatterplot with horizontal lines indicating the mean. Tumor volume was measured and indicated by curves. E–G IHC staining of SMARCE1 and Ki67 for the tumors isolated from the indicated treatment. E Representative image of the staining; F, G percentage of SMARCE1 and Ki67 positive cells were quantified from three independent samples. All data were shown as the mean ± SD, *p < 0.05, **p < 0.01, ***p < 0.001, ns not significant.

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