Fig. 2: Molecular classification of thyroid nodules. | Oncogene

Fig. 2: Molecular classification of thyroid nodules.

From: Distinct molecular subtypes of papillary thyroid carcinoma and gene signature with diagnostic capability

Fig. 2

a Transcriptome-based unsupervised classification of PTC using non-negative matrix factorization (NMF) consensus identified 6 subtypes of thyroid nodules: Benign-I, Immune-enriched, Stromal, BRAF-enriched, Benign-II, CNV-enriched subtypes. b Box plots representing the proportion of tumors greater than 2 cm in diameter, lymph node metastasis, and stage III/IV tumors in each subtype. c Heatmap showing molecular PTC subtypes prediction in TCGA cohort using a predefined gene classifier generated by NMF.

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