Fig. 1: LZTFL1 is significantly down regulated in ccRCC compared to normal tissues. | Oncogene

Fig. 1: LZTFL1 is significantly down regulated in ccRCC compared to normal tissues.

From: LZTFL1 inhibits kidney tumor cell growth by destabilizing AKT through ZNRF1-mediated ubiquitin proteosome pathway

Fig. 1

a The expression level of LZTFL1 in tumor and normal tissues based on data from the TCGA database. b Relative mRNA level as a function of the relative copy number of LZTFL1 in the TCGA database. c Correlation of LZTFL1 mRNA and CNV segment means from ccRCC patients using TCGA level 3 data. d Kaplan–Meier analysis of survival and the COX proportional hazards model for the hazard ratio of LZTFL1 mRNA levels as a prognostic marker in ccRCC patients. e LZTFL1 protein level in ccRCC patient’s tissue samples was compared with those in normal renal tissues in the CPTAC database. *, P < 0.05, **, P < 0.01, ***, P < 0.001, ****, P < 0.0001, NS not significant, unpaired t-test.

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