Fig. 2: p63 expression in the development of epidermis.

A Schematic diagram of epidermal structure. The expression of p63, especially ΔNp63 isoform, is higher in basal cells and decreases during the basal-to-suprabasal transition. B The ESC differentiation program initiates within the basal layer and generates non-stem-committed TA cells, which give rise to the progenitor population, whose progeny finally differentiates into multiple epithelium lineages. C The specific expression of TAp63 and ΔNp63 in different phases during epidermal development. D A cross-section of the hair follicle (HF) and the surrounding epidermis, showing differential expression of p63 isoforms in various HF stem cells subsets.