Fig. 6: A schematic representation of serine-threonine kinase inhibition by PLX8394. | Oncogene

Fig. 6: A schematic representation of serine-threonine kinase inhibition by PLX8394.

From: Inhibition of TGF-β signaling, invasion, and growth of cutaneous squamous cell carcinoma by PLX8394

Fig. 6

PLX8394 inhibits TGF-β signaling by attenuating phosphorylation of TGFβRII and Smad2. Concurrently, PLX8394 inhibits TGF-β-induced Smad2 and p38 activation resulting in decreased MMP-1 and MMP-13 production. PLX8394 does not inhibit p38 activation induced by inflammatory cytokines or environmental stress. As a result, laminin-332 expression is downregulated leading to decreased cSCC cell invasion and tumor growth. The figure was created with BioRender.com.

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