Fig. 2: DKK4 restricts the expansion of CRC xenografts and promotes the metastasis of xenografts in mice.
From: Colorectal cancer cells secreting DKK4 transform fibroblasts to promote tumour metastasis
A–C Tumour images (A), tumour volume (mm3) change curves (B), and tumour weights (C) of harvested xenografts dissected from nude mice harbouring 1597-C-CSCs subcutaneously (s.c.) and treated with human recombinant DKK4 protein (20 mg/kg) or an equal volume of vehicle every 7 days (n ≥ 4). Scale bars, 10 mm. D–F H&E images and quantification of lung metastasis (D, E) and survival curves (F) of nude mice harbouring 1597-CCSCs s.c. and treated with human recombinant DKK4 protein (20 mg/kg) or an equal volumes of vehicle every 7 days (n ≥ 4). The dashed blue line of shDKK4+Veh overlapped with the solid blue line of shDKK4. Scale bars, 100 μm. Mean ± SD, *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001 by Student’s unpaired t test (B, C), Mann‒Whitney u test (E) and log-rank test (F).
