Fig. 3: DKK4 secreted from CRC cells transforms fibroblasts in stromal tissues of xenografts in mice.
From: Colorectal cancer cells secreting DKK4 transform fibroblasts to promote tumour metastasis
A–C Representative images (A) and quantification of Vimentin (red, B) and α-SMA (green, C) immunofluorescence staining in xenografts dissected from nude mice harbouring 1597-CCSCs s.c. and treated with human recombinant DKK4 protein (20 mg/kg) or an equal volume of vehicle every 7 days. Scale bars, 50 μm. At least 3 xenografts were performed in each group, and 3-5 images of each xenograft were taken randomly. Mean ± SD, *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001 by Student’s unpaired t test.
