Fig. 7: DKK4 antibodies modulate fibroblast transformation and the metastasis of xenografts in mouse models.
From: Colorectal cancer cells secreting DKK4 transform fibroblasts to promote tumour metastasis
A–C Tumour images (A), tumour volume (mm3) changing curves (B), and tumour weights (C) of harvested xenografts dissected from nude mice harbouring 1597-CCSCs subcutaneously and administered IgG isotype control or DKK4 antibody (100 mg/kg) every 7 days (n = 3). D–F Representative images (D) and quantification of α-SMA (green, E) and Vimentin (red, F) staining in xenografts of nude mice. Scale bar, 50 μm. G, H Representative images (G) and quantification of MYH9 (green, H) and α-SMA (red) staining in xenografts of nude mice. Scale bar, 50 μm. I–K H&E images and quantification of lung metastasis (I, J) and survival curves (K) of nude mice harbouring 1597-CCSCs subcutaneously and administered IgG isotype control or DKK4 antibody (100 mg/kg) every 7 days (n = 5). Scale bar, 100 μm. Mean ± SD, *p < 0.05; **p < 0.01 by Student’s unpaired t test (B, C, E, F, H, J), and log-rank test (K).
