Fig. 1: Clusters of SCLC cell lines and patient tumors driven by lineage transcription factors.
From: Jumonji histone demethylases are therapeutic targets in small cell lung cancer
Cell lines are shown in red and patient tumors are shown in green in the top bar. Neuroendocrine score, defined by the level of expression of 50 genes that drive the neuroendocrine phenotype [27], is represented on a yellow-to-brown scale. Relative transcription factor expression levels are shown in blue scale and are defined as follows: ASCL1 – A, NEUROD1 – N, YAP1 –Y, and POU2F3 – P. Note that cell lines populate all the clusters defined in patient samples.
