Fig. 6: KDM4 inhibitors decrease the growth rate of H446 and H510 cell line-derived xenograft tumors in vivo and regulate common genes.
From: Jumonji histone demethylases are therapeutic targets in small cell lung cancer
A Growth of H446 xenograft tumors grown in nude mice is significantly suppressed after treatment with JIB-04. Tumor weight was likewise significantly decreased in JIB-04-treated mice. JIB-04 was given via oral gavage three times a week (Mon, Wed, Fri) at 75 mg/kg. Data are shown as mean ± SEM (n = 4 per treatment group). B Growth of H446 xenograft tumors grown in nude mice was suppressed after treatment with SD70. Tumor weight decreased in SD70-treated animals, showing a nearly significant trend. SD70 was given by IP injection Mon-Fri at 10 mg/kg. Data are shown as mean ± SEM (n = 4 per treatment group). C Growth of H510 xenograft tumors grown in nude mice is significantly suppressed after treatment with SD70. Tumor weight was significantly decreased in SD70-treated animals. Data are shown as mean ± SEM (n = 3 per treatment group). ** = p ≤ 0.01, * = p ≤ 0.05, by two-tailed t-test, unequal variance. D Venn diagrams depicting the overlap in upregulated genes (≥1.5 over vehicle) between JIB-04 and SD70 in H446 xenografts (left panel, n = 3 per treatment group) and between SD70-treated H446 vs H510 xenografts (n = 3 per xenograft).
