Table 1 IC50 values of etoposide, JIB-04, SD70, and GSK-J4 across 31 SCLC cell lines representing all transcription factor subgroups.

From: Jumonji histone demethylases are therapeutic targets in small cell lung cancer

 

Etoposide (µM)

JIB-04 (µM)

SD70 (µM)

GSK-J4 (µM)

Cell Line

Assays

IC50

SD

Assays

IC50

SD

Assays

IC50

SD

Assays

IC50

SD

DMS-153

3

0.12

0.02

2

0.105

 

2

1.9

 

2

17.5

 

H1048

6

0.36

0.07

7

0.29

0.093

6

2.35

2.2

4

6.15

8.1

H1092

4

0.26

0.05

2

0.055

 

2

1.95

 

2

6.3

 

H1184

2

0.26

 

3

0.14

0.15

2

1.08

 

1

18

 

H1417

2

0.1

 

10

0.0225

0.17

3

1.4

0.23

3

1

0.41

H146

15

0.1

0.12

8

0.0665

0.44

2

1.15

 

2

3.15

 

H1522

2

1.45

 

3

0.056

0.78

2

1.55

 

3

1.3

0.37

H1876

2

0.08

 

2

0.106

 

2

0.685

 

2

1.55

 

H2107

8

0.71

0.22

3

0.3

0.084

2

3.35

 

2

4

 

H2141

5

1.5

0.34

2

0.195

 

2

1.8

 

2

7.35

 

H2171

18

0.59

0.23

10

0.495

0.29

2

2.1

 

2

12

 

H2679

2

0.56

 

1

>1

 

1

>20

 

2

8.4

 

H345

2

0.25

 

2

0.21

 

2

3.3

 

2

2.35

 

H378

2

17.5

 

2

0.024

 

3

1.2

0.26

2

6.45

 

H446

3

2

0.55

8

0.034

0.019

7

1.2

0.54

5

7.4

6

H510

4

4.45

1.64

5

0.021

0.014

2

2.2

 

2

2.35

 

H524

7

0.29

0.15

6

0.41

0.21

2

2.25

 

3

24

5.8

H526

13

0.23

0.1

3

0.28

0.16

2

1.7

 

2

11.4

 

H69

18

0.88

0.82

8

0.082

0.51

3

1.4

0.17

2

7.5

 

H748

2

0.48

 

3

0.13

0.05

2

1.25

 

2

2

 

H82

21

0.58

0.32

2

0.41

 

2

3.6

 

2

11.5

 

H841

3

9.4

3.78

2

0.38

 

2

1.85

 

2

1.7

 

H889

13

5.7

1.41

3

0.13

0.01

2

1.95

 

2

9.35

 

HCC4000

2

0.44

 

2

0.285

 

2

1.85

 

2

8.65

 

HCC4001

2

0.26

 

4

0.059

0.036

3

1.1

0.23

3

1.6

0.42

HCC4002

4

0.1

0.04

2

0.22

 

2

1.75

 

2

24

 

HCC4003

3

0.28

0.02

3

0.31

0.064

2

2.35

 

2

14

 

HCC4004

2

0.1

 

2

0.18

 

2

1.4

 

2

21

 

HCC4005

2

0.74

 

2

0.205

 

2

1.35

 

2

4

 

HCC970

2

0.23

 

3

0.3

0.38

2

0.9

 

2

5.7

 

SHP-77

2

1.44

 

3

0.16

0.021

2

0.945

 

2

1.04

 
  1. Cells were treated with drugs for 4 days, then cell viability was measured by MTS assay. Shown are median values with standard deviations (n = 2–21).