Table 1 IC50 values of etoposide, JIB-04, SD70, and GSK-J4 across 31 SCLC cell lines representing all transcription factor subgroups.
From: Jumonji histone demethylases are therapeutic targets in small cell lung cancer
Etoposide (µM) | JIB-04 (µM) | SD70 (µM) | GSK-J4 (µM) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cell Line | Assays | IC50 | SD | Assays | IC50 | SD | Assays | IC50 | SD | Assays | IC50 | SD |
DMS-153 | 3 | 0.12 | 0.02 | 2 | 0.105 | 2 | 1.9 | 2 | 17.5 | |||
H1048 | 6 | 0.36 | 0.07 | 7 | 0.29 | 0.093 | 6 | 2.35 | 2.2 | 4 | 6.15 | 8.1 |
H1092 | 4 | 0.26 | 0.05 | 2 | 0.055 | 2 | 1.95 | 2 | 6.3 | |||
H1184 | 2 | 0.26 | 3 | 0.14 | 0.15 | 2 | 1.08 | 1 | 18 | |||
H1417 | 2 | 0.1 | 10 | 0.0225 | 0.17 | 3 | 1.4 | 0.23 | 3 | 1 | 0.41 | |
H146 | 15 | 0.1 | 0.12 | 8 | 0.0665 | 0.44 | 2 | 1.15 | 2 | 3.15 | ||
H1522 | 2 | 1.45 | 3 | 0.056 | 0.78 | 2 | 1.55 | 3 | 1.3 | 0.37 | ||
H1876 | 2 | 0.08 | 2 | 0.106 | 2 | 0.685 | 2 | 1.55 | ||||
H2107 | 8 | 0.71 | 0.22 | 3 | 0.3 | 0.084 | 2 | 3.35 | 2 | 4 | ||
H2141 | 5 | 1.5 | 0.34 | 2 | 0.195 | 2 | 1.8 | 2 | 7.35 | |||
H2171 | 18 | 0.59 | 0.23 | 10 | 0.495 | 0.29 | 2 | 2.1 | 2 | 12 | ||
H2679 | 2 | 0.56 | 1 | >1 | 1 | >20 | 2 | 8.4 | ||||
H345 | 2 | 0.25 | 2 | 0.21 | 2 | 3.3 | 2 | 2.35 | ||||
H378 | 2 | 17.5 | 2 | 0.024 | 3 | 1.2 | 0.26 | 2 | 6.45 | |||
H446 | 3 | 2 | 0.55 | 8 | 0.034 | 0.019 | 7 | 1.2 | 0.54 | 5 | 7.4 | 6 |
H510 | 4 | 4.45 | 1.64 | 5 | 0.021 | 0.014 | 2 | 2.2 | 2 | 2.35 | ||
H524 | 7 | 0.29 | 0.15 | 6 | 0.41 | 0.21 | 2 | 2.25 | 3 | 24 | 5.8 | |
H526 | 13 | 0.23 | 0.1 | 3 | 0.28 | 0.16 | 2 | 1.7 | 2 | 11.4 | ||
H69 | 18 | 0.88 | 0.82 | 8 | 0.082 | 0.51 | 3 | 1.4 | 0.17 | 2 | 7.5 | |
H748 | 2 | 0.48 | 3 | 0.13 | 0.05 | 2 | 1.25 | 2 | 2 | |||
H82 | 21 | 0.58 | 0.32 | 2 | 0.41 | 2 | 3.6 | 2 | 11.5 | |||
H841 | 3 | 9.4 | 3.78 | 2 | 0.38 | 2 | 1.85 | 2 | 1.7 | |||
H889 | 13 | 5.7 | 1.41 | 3 | 0.13 | 0.01 | 2 | 1.95 | 2 | 9.35 | ||
HCC4000 | 2 | 0.44 | 2 | 0.285 | 2 | 1.85 | 2 | 8.65 | ||||
HCC4001 | 2 | 0.26 | 4 | 0.059 | 0.036 | 3 | 1.1 | 0.23 | 3 | 1.6 | 0.42 | |
HCC4002 | 4 | 0.1 | 0.04 | 2 | 0.22 | 2 | 1.75 | 2 | 24 | |||
HCC4003 | 3 | 0.28 | 0.02 | 3 | 0.31 | 0.064 | 2 | 2.35 | 2 | 14 | ||
HCC4004 | 2 | 0.1 | 2 | 0.18 | 2 | 1.4 | 2 | 21 | ||||
HCC4005 | 2 | 0.74 | 2 | 0.205 | 2 | 1.35 | 2 | 4 | ||||
HCC970 | 2 | 0.23 | 3 | 0.3 | 0.38 | 2 | 0.9 | 2 | 5.7 | |||
SHP-77 | 2 | 1.44 | 3 | 0.16 | 0.021 | 2 | 0.945 | 2 | 1.04 | |||