Fig. 6: PRNP levels are associated with resistance to EGFR-TKI. | Oncogene

Fig. 6: PRNP levels are associated with resistance to EGFR-TKI.

From: PrPC controls epithelial-to-mesenchymal transition in EGFR-mutated NSCLC: implications for TKI resistance and patient follow-up

Fig. 6

Boxplots showing the distribution of PRNP mRNA in (A) erlotinib-resistant HCC827 clones versus parental cells (B) the minimal residual cell population obtained after combined treatment of HCC827 cells with osimertinib and trametinib (C) HCC827 cells acutely exposed to osimertinib (left) or HCC827 persister cells after long-term exposure osimertinib (right). D Quantification of cell numbers in H1975 cells pre-treated or not with PRNP siRNA and exposed to different doses of osimertinib for 72 h, according to the schematic workflow (top). E Differential expression of PRNP is shown in violin plots for single cancer cells collected from a patient treated with erlotinib (left) or a patient treated with osimertinib (right). TN treatment naive, RD residual disease, PD progressive disease.

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