Fig. 3: Sex-dependent differences in the tumor spectrum between long-lived male and long-lived female mice.

a Complete histological analysis was performed for diseased long-lived mice (25 females and 17 males) with an average age of 28.2 months. The percentage indicates the incidence of tumor categories among the mice analyzed. Some mice had more than one tumor type. In females, myeloid leukemia included AML and B/myeloid MPAL; ovarian tumors included ovarian carcinoma and hemangiosarcoma; and other tumors included adenocarcinoma and soft tissue sarcoma in other organs. In males, other tumors included renal cell carcinoma, hepatoma, hemangiosarcoma and adenocarcinoma. b, c Flow cytometry analysis of a long-lived female BALB/c mouse bearing B/M MPAL that was partially CD3e positive (b) compared to the tail blood of 4-month-old and healthy 29-month-old females, with the latter displaying strong myeloid skewing (c).