Fig. 2: Genetic and epi-genetic phylogenies for patients.
From: Evidence of DNA methylation heterogeneity and epipolymorphism in kidney cancer tissue samples
Phylogenies using DNA methylation and copy number data are compared for each patient, for patients 5532 (A), 7067 (B) and 5813 (C). Multi-region tumour samples are denoted with a T, where each sample is labelled numerically to demarcate tumours from the same patient. Normal samples as denoted with an N. Monophyletic clades which are present in both phylo-epigenetic and phylogenetic trees are shown in red, with other similarities shown in green. In patients 5532 and 7067 extremely similar methylation and SCNA trees were noted, suggesting potential co-evolution, whereas 5813 demonstrated distinctly different phylogenetic and phylo-epigenetic trees, indicating that potentially methylation and SCNA changes may have evolved separately.
