Fig. 3: An overview of the potential anti- and pro-tumorigenic activity of the IL-36 and IL-38 cytokines.
From: The complex roles of IL-36 and IL-38 in cancer: friends or foes?
These cytokines (particularly IL-36γ) display broad anti- and pro-tumorigenic roles across a variety of malignancies. The anti-tumorigenic functions involve enhancing the suppressive activity of the immune system. In contrast, the pro-tumorigenic functions promote immune evasion and cell proliferation.
